I have setup multiple websites / business units, and have been working for myself for the last 9 months.
These are my businesses:
1. www.bluestormacademy.com – Life coaching and peak performance
2. www.freshzeal.com – Webdesign and promotion
3. www.yourrobotbutler.com – Online Personal Assistants, and Timemanagement coaching
4. www.zoneidentity.com – Domain broker (site not finished)
It is going well, and this year is all about focusing on ramping up sales and really scaling all these business units. :-)