Dear 43 Things Users,

10 years after introducing 43 Things to the world, we have decided we have met our last goal: completing the incredible experience that has been 43 Things. Please join us in giving one last cheer to all the folks who have shared their goals with the world, as well as all the people who have worked at The Robot Co-op to build this incredible website. We won a Webby Award, published a book, and brought happiness to a lot of people.

Starting today, 43 Things users can export their goals and entries from the site. Starting August 15, we will make the site “read only”. 43 Things users will still be able to view the site and export their content, but we won’t be taking any new content from users. We hope to leave the site up for folks to see and download their content until the end of the year. Ending on New Year’s Eve takes us full circle.

It has been a long ride (one of our original goals was to "build a company that lasts at least 2 years” - we beat that one!) While we wish the site could live on, it has suffered from a number of challenges - changes in how people use the site, the advertising industry, and how search engines view the site. We wish the outcome was different – but we’ve always been realistic about when our goals are met and when they aren't.

As of today, you will be able to download your goals and entries. See more about that on the FAQ page. Thanks for 10 great years of goal-setting and achieving.

- The Robots.

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Understand the human body--parts, functions & operations.


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SGVery Basic

Thyroid = Small Gland in front of neck (weighs less than an ounce).

  • Has 2 lobes that lie along the windpipe (trachea)
  • The lobes and are joined by a band of thyroid tissue (Called the Isthmus).

The Gland
burns energy

make proteins

determines sensitivity to other hormones.

I move beyond old limitations and allow myself to express freely and creatively.4 years ago

SGThe thyroid

The thyroid is in charge of directing the body to:

burn energy,
make proteins,
determine how sensitive the body should be to other hormones.

So imagine the thyroid is a person. Her job description would be to determine what metabolism you shall receive—sort of like a task similar to a boss determining what pay raise an employee would receive.

And like at a job, in some instances, if you do certain things, then you get a better metabolism (just like a good pay raise). In other instances, you may feel like you are just SOL.

I’m not sure about the job of directing the “making of proteins”. That is something I have to learn more about.

I guess Ms. Thyroid is like the leader of the body’s United Nations, because she is in charge of telling the body how to react to all the other hormones, which include:

Thyroid-stimulating hormone (TSH) protein (201) Anterior lobe of pituitary
Follicle-stimulating hormone (FSH) protein (204)
Luteinizing hormone (LH) protein (204)
Prolactin (PRL) protein (198)
Growth hormone (GH) protein (191)
Adrenocorticotropic hormone (ACTH) peptide (39)
Vasopressin peptide (9) Posterior lobe of pituitary
Oxytocin peptide (9)
Thyrotropin-releasing hormone (TRH) peptide (3) Hypothalamus
Gonadotropin-releasing hormone (GnRH) peptide (10)
Growth hormone-releasing hormone (GHRH) peptides (40, 44)
Corticotropin-releasing hormone (CRH) peptide (41)
Somatostatin peptides (14, 28)
Dopamine tyrosine derivative
Melatonin tryptophan derivative Pineal gland
Thyroxine (T4) tyrosine derivative Thyroid Gland
Calcitonin peptide (32)
Parathyroid hormone (PTH) protein (84) Parathyroid glands
Glucocorticoids (e.g., cortisol) steroids Adrenal cortex
Mineralocorticoids (e.g., aldosterone) steroids
Androgens (e.g., testosterone) steroids
Adrenaline (epinephrine) tyrosine derivative Adrenal medulla
Noradrenaline (norepinephrine) tyrosine derivative
Estrogens (e.g., estradiol) steroid Ovarian follicle
Progesterone steroid Corpus luteum and placenta
Human chorionic gonadotropin (HCG) protein (237) Trophoblast and placenta
Androgens (e.g., testosterone) steroid Testes
Insulin protein (51) Pancreas (Islets of Langerhans)
Glucagon peptide (29)
Somatostatin peptides (14, 28)
Amylin peptide (37)
Erythropoietin (EPO) protein (166) Kidney
Calcitriol steroid derivative
Calciferol (vitamin D3) steroid derivative Skin
Atrial-natriuretic peptide (ANP) peptides (28, 32) Heart
Gastrin peptides (e.g., 14) Stomach and intestine
Secretin peptide (27)
Cholecystokinin (CCK) peptides (e.g., 8)
Incretins peptides (e.g., 31, 42)
Somatostatin peptides (14, 28)
Neuropeptide Y peptide (36)
Ghrelin peptide (28)
PYY3-36 peptide (34)
Serotonin tryptophan derivative
Insulin-like growth factor-1 (IGF-1) protein (70) Liver
Angiotensinogen protein (485)
Thrombopoietin protein (332)
Leptin protein (167) Fat cells (adipocytes)
Retinol Binding Protein 4 protein (~180)
Adiponectin protein (117)

That’s a LOT of hormones to affect if you’re the thyroid. So, if the thyroid is not working properly, different parts of the body can be greatly affected. Sort of like, if the CEO of a company is not competent, she/he can really make a mess of things (using these analogies to drill this information into my head).

...continued 5 years ago

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