I tried to keep it simple. I moved the obvious stuff to the appropriate folders like docs, photos, videos, etc.
Next on all the internal drives I separated them into gaming, work, videography projects, and lastly my podcast show stuff.
I keep nothing on the desktop anymore, and even organized the launcher at the bottom to only apps I use, and not the standard Apple apps.
Now my Mac and I love each other again. I treated it with a brand new 2Tb Time Machine drive. You are welcome Mac. (Tussles the Mac’s hair) 12 months ago